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Abstract #2266

High reproducibility of sandwich spatial saturation neuromelanin imaging (sandwichNM): multicenter and test-retest results

Sooyeon Ji1, Eun-Jung Choi1, Beomseok Sohn2, Eung Yeop Kim3, Kyoungwon Baik2, Na-Young Shin4, Won-Jin Moon5, Seongbeom Park6, Soohwa Song6, Phil Hyu Lee7, Dong Hoon Shin6, and Jongho Lee1
1Seoul National University, Seoul, Korea, Republic of, 2Severance Hospital, Seoul, Korea, Republic of, 3Department Radiology, Samsung Medical Center, Seoul, Korea, Republic of, 4Department Radiology, Catholic University of Korea, Seoul, Korea, Republic of, 5Department of Radiology, Konkuk University Medical Center, Seoul, Korea, Republic of, 6Heuron Co. Ltd., Incheon, Korea, Republic of, 7Department of Neurology, Severance Hospital, Seoul, Korea, Republic of


The reproducibility of the recently proposed sandwich spatial saturation neuromelanin (sandwichNM) imaging, which uses product sequences, is evaluated by a multi-center/multi-vendor traveling-subject study. Additionally, test-retest scans acquiring data in two different days are performed and evaluated. When compared to a conventional MT-weighted GRE NM imaging method, sandwichNM demonstrates higher contrast ratios and smaller variations across scanners, and higher intra-class coefficient and lower coefficient of variation in the test and retest scans, revealing higher reproducibility over the conventional method.

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