The reproducibility of the recently proposed sandwich spatial saturation neuromelanin (sandwichNM) imaging, which uses product sequences, is evaluated by a multi-center/multi-vendor traveling-subject study. Additionally, test-retest scans acquiring data in two different days are performed and evaluated. When compared to a conventional MT-weighted GRE NM imaging method, sandwichNM demonstrates higher contrast ratios and smaller variations across scanners, and higher intra-class coefficient and lower coefficient of variation in the test and retest scans, revealing higher reproducibility over the conventional method.
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