Abstract #2267
Brain correlates of voice disorders in early Parkinson’s disease
Laetitia Jeancolas1,2, Sandy Mournet1,2,3,4, Cécile Gallea1,2, Emma Biondetti1,2, Graziella Mangone3,5,6, Lydia Chougar1,2,3,4, Nicolas Villain7, Rahul Gaurav1,2, Habib Benali8, Badr-Eddine Benkelfat9, Isabelle Arnulf3,10, Marie-Odile Habert3,11, Dijana Petrovska-Delacrétaz9, Marie Vidailhet2,3,6, Jean-Christophe Corvol3,5,6, and Stéphane Lehéricy1,2,3,4
1Centre de NeuroImagerie de Recherche – CENIR, Institut du Cerveau – ICM, Paris, France, 2Team “Movement Investigations and Therapeutics”(MOV'IT), Institut du Cerveau – ICM, Paris, France, 3Sorbonne University, Inserm, CNRS, Paris Brain Institute - ICM, Paris, France, 4Department of Neuroradiology, AP-HP, Pitié-Salpêtrière Hospital, Paris, France, 5Clinical Investigation Center for Neurosciences, Pitié-Salpêtrière Hospital, INSERM, Paris, France, 6Department of Neurology, AP-HP, Pitié-Salpêtrière Hospital, Paris, France, 7AP-HP, Pitié-Salpêtrière Hospital, Paris, France, 8PERFORM Centre, Electrical & Computer Engineering Department, Concordia University, Montreal, QC, Canada, 9Laboratoire SAMOVAR, Télécom SudParis, Institut Polytechnique de Paris, Paris, France, 10Sleep disorders unit, AP-HP, Pitié-Salpêtrière Hospital, Paris, France, 11Department of Nuclear Medicine, AP-HP, Pitié-Salpêtrière Hospital, Paris, France
Synopsis
We studied the neural mechanisms underlying Parkinson’s disease (PD) speech impairments. We assessed the relationships between the speech impairment in PD and changes in the nigrostriatal system (DAT imaging and neuromelanin-sensitive MRI) and in resting state fMRI functional connectivity within cortical language networks. Patients presented speech alterations depending on gender. Dopaminergic loss in the striatum as well as functional connectivity between the basal ganglia and the cortex were related to PD speech impairments in men, whereas in women only functional connectivity seemed to play a role in PD speech deterioration.
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