In this study, we used surface-based morphometry analysis to evaluate the correlation between structural alterations in the brains of Parkinson’s disease (PD) subjects, impaired cognition, and gait. Our results showed that cortical surface area in the left lateral temporal cortex (LTC) and right inferior parietal cortex (IPC) was significantly larger in the PD subjects compared to the healthy subjects. Furthermore, these cortical structural changes were associated with gait impairments in the PD subjects. Therefore, surface area-based analysis is a useful tool for assessing progression of gait impairments in PD subjects.
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