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Abstract #2269

Thalamic volume and lateralization on Parkinson Disease associated with cognitive and motor deficits

Vicente Jose Ferrer-Gallardo1, Teresa Esteban-Peñalba2, César Caballero-Gaudes1, and Pedro M Paz-Alonso2
1Signal processing in neuroimaging, Basque Center on Cognition Brain and language, San Sebastian, Spain, 2Language and memory control, Basque Center on Cognition Brain and language, San Sebastian, Spain


This study sheds light on the relationship between the thalamic nuclei volume and their lateralization with cognitive and motor scores in PD. Two partial least squares analyses were performed between the volume or laterality indexes of all nuclei and clinical and cognitive scores. Cognitive deficits in semantic fluency and symbols and digits tests in PD are related to ventral, central and medial thalamic nuclei rather than to specific nuclei differences, except for the right-AV. Motor deterioration seems to be reflected in specific lateralization of the medial and pulvinar areas.

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