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Abstract #2270

Evaluating iron overload in Nigrosome 1 via Quantitative Susceptibility Mapping at 7T in prodromal stages of Parkinson’s disease

Marta Lancione1,2, Graziella Donatelli2,3, Eleonora Del Prete4, Nicole Campese4, Daniela Frosini4, Matteo Cencini1,2, Mauro Costagli1,5, Giacomo Lucchi6, Michela Tosetti1,2, Massimiliano Godani7, Dario Arnaldi5,8, Michele Terzaghi9,10, Claudio Pacchetti11, Pietro Cortelli12,13, Enrica Bonanni4, Roberto Ceravolo4, and Mirco Cosottini6
1IRCCS Stella Maris, Pisa, Italy, 2Imago7 Research Foundation, Pisa, Italy, 3Neuroradiology Unit, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy, 4Neurology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, 5Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Sciences (DINOGMI), University of Genoa, Genoa, Italy, 6Neuroradiology Unit, Department of Translational Research on New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy, 7Neurology Unit, Sant'Andrea Hospital, La Spezia, Italy, 8IRCCS Ospedale Policlinico San Martino, Genoa, Italy, 9Unit of Sleep Medicine and Epilepsy, IRCCS Mondino Foundation, Pavia, Italy, 10Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy, 11Parkinson's Disease and Movement Disorders Unit, IRCCS Mondino Foundation, Pavia, Italy, 12Clinica Neurologica Rete Metropolitana, IRCCS Istituto Scienze Neurologiche Bologna, Bologna, Italy, 13Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy


iRBD is a prodromal stage of α-synucleinopathies, like PD. Iron deposition is increased in the substantia nigra of PD patients, mainly in Nigrosome-1 (N1). Here, we estimated N1 iron content in PD, iRBD patients and healthy controls using QSM at 7T to investigate group differences and correlation with disease duration. PD patients showed increased N1 susceptibility compared to controls and iRBD patients but no correlation with disease duration. N1 susceptibility in iRBD patients was not different from controls but correlated with disease duration. Hence, in prodromal stages of α-synucleinopathies, QSM can reveal progressive N1 iron accumulation as the disease evolves.

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