Cerebral oxygen extraction fraction (OEF) mapping in cognitively impaired and intact elderly
Junghun Cho1, Gloria C Chiang1, Jonathan Dyke1, Hang Zhang2, Qihao Zhang2, Michael Tokov3, Thanh D Nguyen1, Pascal Spincemaille1, Ilhami Kovanlikaya1, Michael Amoashiy4, Mony de Leon1, and Yi Wang1,2
1Radiology, Weill Cornell Medicine, New York, NY, United States, 2Biomedical Engineering, Cornell University, Ithaca, NY, United States, 3College of Osteopathic Medicine, New York Institute of Technology, Glen Head, NY, United States, 4Neurology, Weill Cornell Medicine, New York, NY, United States
Cerebral metabolic dysfunction is known to underlie cognitive impairment. This study using a novel challenge-free MRI-based oxygen extraction fraction (OEF) mapping method, namely “QQ”, demonstrated that lower OEF in white matter and hippocampus was associated with greater white matter hyperintensities in cognitively impaired, but not cognitively intact, elderly, whereas older age was association with decreased OEF in cortical gray matter in the cognitively intact. This study suggests that QQ-based OEF mapping may be a useful tool readily and widely available for investigating metabolic dysfunction underlying dementia.
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