Cerebral metabolic dysfunction is known to underlie cognitive impairment. This study using a novel challenge-free MRI-based oxygen extraction fraction (OEF) mapping method, namely “QQ”, demonstrated that lower OEF in white matter and hippocampus was associated with greater white matter hyperintensities in cognitively impaired, but not cognitively intact, elderly, whereas older age was association with decreased OEF in cortical gray matter in the cognitively intact. This study suggests that QQ-based OEF mapping may be a useful tool readily and widely available for investigating metabolic dysfunction underlying dementia.
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