Abstract #2278
Automatic DTI measures in the superficial white matter associated with cognitive decline and CSF amyloid-β42 in neurodegenerative dementia
Valeria Elisa Contarino1, Silvia Siggillino1, Andrea Arighi1, Elisa Scola1, Giorgio Giulio Fumagalli1, Giorgio Conte1,2, Emanuela Rotondo1, Daniela Galimberti1, Anna Margherita Pietroboni1, Tiziana Carandini1, Alexander Leemans3, Anna Maria Bianchi4, and Fabio Maria Triulzi1,2
1Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano, Milano, Italy, 2Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milano, Italy, 3Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands, 4Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milano, Italy
Synopsis
Diffusion tensor imaging (DTI) studies showed superficial white matter (SWM) alterations in Alzheimer’s disease (AD). The study aims to investigate the relationship between DTI in the SWM and CSF biomarkers in neurodegenerative dementia (ND). 93 ND patients were retrospectively recruited and images were processed for automatic segmentation of lobar white matter and Diffusion tensor imaging (DTI). Spearman’s correlation tests were performed between lobar DTI measures in the SWM, CSF biomarkers and clinical data. DTI measures in the SWM strongly correlated with Mini-Mental State Examination (MMSE) and amyloid-β42 suggesting SWM DTI as a candidate in-vivo non-invasive clinical and preclinical biomarker.
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