Diffusion tensor imaging (DTI) studies showed superficial white matter (SWM) alterations in Alzheimer’s disease (AD). The study aims to investigate the relationship between DTI in the SWM and CSF biomarkers in neurodegenerative dementia (ND). 93 ND patients were retrospectively recruited and images were processed for automatic segmentation of lobar white matter and Diffusion tensor imaging (DTI). Spearman’s correlation tests were performed between lobar DTI measures in the SWM, CSF biomarkers and clinical data. DTI measures in the SWM strongly correlated with Mini-Mental State Examination (MMSE) and amyloid-β42 suggesting SWM DTI as a candidate in-vivo non-invasive clinical and preclinical biomarker.
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