Abstract #2279
Longitudinal Assessment of Intravoxel Incoherent Motion Diffusion-Weighted MRI (IVIM-DWI) Metrics in Alzheimer’s Disease
Maurizio Bergamino1, Lori Steffes2, Anna Burke3, Leslie C Baxter4, Richard J Caselli4, Marwan N Sabbagh5, and Ashley M Stokes1
1Neuroimaging Division, Barrow Neurological Institute, Phoenix, AZ, United States, 21Neuroimaging Division, Barrow Neurological Institute, Phoenix, AZ, United States, 3Division of Neurology, Barrow Neurological Institute, Phoenix, AZ, United States, 4Department of Neurology, Mayo Clinic Arizona, Phoenix, AZ, United States, 5Alzheimer's and Memory Disorders Division, Barrow Neurological Institute, Phoenix, AZ, United States
Synopsis
The objective of this pilot study was to assess the complementary brain microstructural and perfusion changes using the apparent diffusion coefficient (ADC) and the intravoxel incoherent motion-diffusion weighted imaging (IVIM-DWI) parameters in a group of cognitively impaired people over a period of 12 months. Additionally, voxel-based correlations between cognitive assessment scores and DWI imaging parameters were evaluated.
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