Abstract #2279

Longitudinal Assessment of Intravoxel Incoherent Motion Diffusion-Weighted MRI (IVIM-DWI) Metrics in Alzheimer’s Disease

Maurizio Bergamino¹, Lori Steffes², Anna Burke³, Leslie C Baxter⁴, Richard J Caselli⁴, Marwan N Sabbagh⁵, and Ashley M Stokes¹

¹Neuroimaging Division, Barrow Neurological Institute, Phoenix, AZ, United States, ²1Neuroimaging Division, Barrow Neurological Institute, Phoenix, AZ, United States, ³Division of Neurology, Barrow Neurological Institute, Phoenix, AZ, United States, ⁴Department of Neurology, Mayo Clinic Arizona, Phoenix, AZ, United States, ⁵Alzheimer's and Memory Disorders Division, Barrow Neurological Institute, Phoenix, AZ, United States

Synopsis

The objective of this pilot study was to assess the complementary brain microstructural and perfusion changes using the apparent diffusion coefficient (ADC) and the intravoxel incoherent motion-diffusion weighted imaging (IVIM-DWI) parameters in a group of cognitively impaired people over a period of 12 months. Additionally, voxel-based correlations between cognitive assessment scores and DWI imaging parameters were evaluated.

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