Abstract #2283

Prediction of MCI conversion using sulcal morphometry

Giovanni Sighinolfi¹, Micaela Mitolo^2,3, Fabrizio Pizzagalli⁴, Raffaele Lodi^1,2, Michelangelo Stanzani-Maserati⁵, Daniel Remondini⁶, Sabina Capellari^1,5, Rocco Liguori^1,5, Caterina Tonon^1,2, and Claudia Testa^2,6

¹Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy, ²Functional and Molecular Neuroimaging Unit, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy, ³Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy, ⁴Department of Neurosciences "Rita Levi Montalcini", University of Torino, Torino, Italy, ⁵UOC Clinica Neurologica, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy, ⁶Department of Physics and Astronomy, University of Bologna, Bologna, Italy

Synopsis

We investigated the capabilities of brain sulcal morphometry and cortical thickness (CT) to predict the conversion from MCI stage to AD and explored the correlation with neuropsychological performance. Sulcal surface, mean depth, length and width were analysed. The width showed the best capability to discriminate between HC, MCI and AD (also in comparison to CT), and was able to distinguish at baseline converter MCI from non-converter MCI. Moreover, the width of specific frontal sulci correlated with memory and language performance.

Sulcal morphometry emerged as a useful tool, capable of providing potential biomarkers for MCI conversion.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.