Abstract #2282
Comparison of vein diameter and susceptibility values in individuals with and without APOE ε4 allele
Julia Huck1,2, Nathan Spreng3,4,5, Brittany Intzandt1,2,6,7, PREVENT-AD Research Group8, Sylvia Villeneuve5,9, Mallar Chakravarty9, Pierre-Louis Bazin10,11,12, and Claudine Gauthier1,2,7
1Concordia University, Montreal, QC, Canada, 2PERFORM Centre, Concordia University, Montreal, QC, Canada, 3Laboratory of Brain and Cognition, Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada, 4Departments of Psychiatry and Psychology, Neurological Institute, McGill University, Montreal, QC, Canada, 5McConnell Brain Imaging Centre, Montreal Neurological Institute (MNI), McGill University, Montreal, QC, Canada, 6Centre de Recherche de l’Institut Universitaire de Geriatrie de Montreal, Montreal, QC, Canada, 7Centre de Recherche de l’Institut de Cardiologie de Montreal, Montreal, QC, Canada, 8StoP-AD Centre, Douglas Mental Health Institute Research Centre, Montreal, QC, Canada, 9Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada, 10Psychology, University of Amsterdam, Amsterdam, Netherlands, 11Neurophysics, Max Planck Institute for Human Cognitive and Brian Sciences, Leipzig, Germany, 12Neurology, Max Planck Institute for Human Cognitive and Brian Sciences, Leipzig, Germany
Synopsis
Previous studies have shown an increase in oxygen extraction fraction (OEF) in individuals with Alzheimer’s disease (AD). Here, we investigate if vein diameters and susceptibility values measured with quantitative susceptibility maps (QSM), can be used as a biomarker in individuals with the APOE ε4 allele, which confers an increased risk of developing AD for detecting early changes in venous and metabolic properties.
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