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Abstract #2287

Simultaneous T1, T2, and T2* Mapping of the Liver in a Single Breath Hold Using Multi Inversion Spin and Gradient Echo

Mary Kate Manhard1,2, Amol S. Pednekar1,2, Hui Wang1,2,3, Jean A. Tkach1,2, and Jonathan R. Dillman1,2
1Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 2Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, United States, 3Clinical Science, Philips Healthcare, Cincinnati, OH, United States


Parametric mapping aids in the non-invasive evaluation and longitudinal monitoring of diffuse chronic liver disease. Commercially available parametric mapping techniques require multiple scans over multiple breath-holds. A multi-inversion spin and gradient echo (MI-SAGE) method is presented to simultaneously estimate T1, T2, and T2* at six slice locations in the liver in a single 16s breath-hold. In five volunteers, the MI-SAGE method produced parametric values comparable to those obtained using modified Lock Locker (T1), multiple gradient and spin echo (T2), and multiple gradient echo (T2*) sequences. MI-SAGE offers the potential to significantly shorten the duration of the quantitative MR liver exams.

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