Parametric mapping aids in the non-invasive evaluation and longitudinal monitoring of diffuse chronic liver disease. Commercially available parametric mapping techniques require multiple scans over multiple breath-holds. A multi-inversion spin and gradient echo (MI-SAGE) method is presented to simultaneously estimate T1, T2, and T2* at six slice locations in the liver in a single 16s breath-hold. In five volunteers, the MI-SAGE method produced parametric values comparable to those obtained using modified Lock Locker (T1), multiple gradient and spin echo (T2), and multiple gradient echo (T2*) sequences. MI-SAGE offers the potential to significantly shorten the duration of the quantitative MR liver exams.