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Abstract #2290

L-carnitine Supplementation used as a Tool for Detecting Hepatic Flexibility of Acetylcarnitine using 1H Magnetic Resonance Spectroscopy.

Dragana Savic1, Ferenc E. Mózes1, Peregrine G. Green1, Matthew K. Burrage1, Gabrielle Allen2, Timothy James2, Leanne Hodson1, Stefan Neubauer1, Michael Pavlides1, and Ladislav Valkovič1
1University of Oxford, Oxford, United Kingdom, 2Oxford University Hospitals, Oxford, United Kingdom


This study investigated the in vivo effects on acetylcarnitine levels in the liver after an injection of L-carnitine. L-carnitine facilitates transport of fatty acids into the mitochondria. We show that a single injection of L-carnitine modulated acetylcarnitine levels in the liver and that it modulated several blood markers in the healthy volunteer. Further studies are needed to understand the plasma metabolic changes observed with L-carnitine supplementation.

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