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Abstract #2291

Test-retest reliability of in-vivo 31P MRSI of the whole human liver at 7 Tesla using a 31P whole-body transmit coil and 16-channel receive array

Lieke van den Wildenberg1, Ayhan Gursan1, Leonard W.F. Seelen1, Tijl A. van der Velden1, Mark Gosselink1, Martijn Froeling1, Wybe J.M. van der Kemp1, Dennis Klomp1, and Jeanine Prompers1
1Imaging and Oncology, UMC Utrecht, Utrecht, Netherlands


Alterations in 31P metabolite concentrations in the liver can be a consequence of liver disease and therefore 3D 31P MRSI can help in diagnosis and following progression and treatment response. However, commonly used 31P surface coils have a limited penetration depth and do not provide full coverage of the liver. We used an integrated 31P whole-body transmit coil with a local 31P receive array for 31P MRSI of the liver at a 7T MRI scanner. Here we demonstrate that 31P signals can be measured throughout the liver and 31P metabolite levels can be quantified with good to excellent test-retest reliability.

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