The mortality rate for patients with acute myeloid leukemia (AML) is still high. Cytogenetic features are the most important prognostic parameter, and the most appropriate treatment of intermediate risk AML (IR-AML), which accounts for about 60% of AML, is controversial. Our study suggested that the D value obtained from intravoxel incoherent motion (IVIM) could play a potential role in predicting treatment response of IR-AML patients. Moreover, f value and D* value in an IVIM model can independently predict OS of patients with IR-AML. These findings suggest that IVIM parameters can be useful imaging markers to predict prognosis for IR-AML.