The aim of this work was to identify focal changes in T2 relaxation times inside and outside regions of tibiofemoral contact in loaded cadaver knee articular cartilage. We used a cluster analysis approach to identify focal regions of change in T2 relaxation time. We found clusters of increased and decreased T2 relaxation time when the cartilage was loaded; the majority of the clusters of decreased T2 relaxation time were observed within the tibial and femoral cartilage contact area.
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