Abstract #2303

Topographical Associations of Knee Cartilage MRI with Osteoarthritis Pain: Data from the Osteoarthritis Initiative.

Edward J Peake^1,2, Tom D Turmezei^3,4, and Dorothee P Auer^1,2

¹Radiological Sciences, Division of Clinical Neuroscience, University of Nottingham, Nottingham, United Kingdom, ²NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom, ³Department of Radiology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, United Kingdom, ⁴Norwich Medical School, University of East Anglia, Norwich, United Kingdom

Synopsis

Pain is a hallmark of knee osteoarthritis, a chronic condition with considerable health and socioeconomic burden. Osteoarthritic changes of the knee cartilage are often used as an outcome marker for clinical trials, but only weakly associated with pain. In this study, we aimed to examine the topographic correlation between intensity differences in knee cartilage MRI and knee pain. Voxel based morphometry (VBM) is used with linear effects modelling to show the spatial localization of knee OA contributing to pain. Local maxima and clusters with extents with P<0.05 are determined using random field theory.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.