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Abstract #2303

Topographical Associations of Knee Cartilage MRI with Osteoarthritis Pain: Data from the Osteoarthritis Initiative.

Edward J Peake1,2, Tom D Turmezei3,4, and Dorothee P Auer1,2
1Radiological Sciences, Division of Clinical Neuroscience, University of Nottingham, Nottingham, United Kingdom, 2NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom, 3Department of Radiology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, United Kingdom, 4Norwich Medical School, University of East Anglia, Norwich, United Kingdom


Pain is a hallmark of knee osteoarthritis, a chronic condition with considerable health and socioeconomic burden. Osteoarthritic changes of the knee cartilage are often used as an outcome marker for clinical trials, but only weakly associated with pain. In this study, we aimed to examine the topographic correlation between intensity differences in knee cartilage MRI and knee pain. Voxel based morphometry (VBM) is used with linear effects modelling to show the spatial localization of knee OA contributing to pain. Local maxima and clusters with extents with P<0.05 are determined using random field theory.

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