Meeting Banner
Abstract #2312

Peri-conceptional Alcohol Exposure Shapes Placental Functions in Fetal Alcohol Spectrum Disorder

Margaret Caroline Stapleton 1, John Richard Chaillet 2, Eric Goetzman3, Devin R. E. Cortes4, Kristina Elsa Schwab1, Amanda Sferruzzi-Perri 5, Michal Neeman6, Anthony Christodoulou 7, and Yijen L Wu1
1Developmental Biology, University of Pittsburgh, Pittsburgh, PA, United States, 2Obstetrics, Gynecology & Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA, United States, 3Pediatrics, University of Pittsburgh, Pittsburgh, PA, United States, 4Biomedical Engineering, University of Pittsburgh, Pittsburgh, PA, United States, 5Physiology, University of Cambridge, Cambridge, United Kingdom, 6Biological Regulation, Weizmann Institute, Rehovot, Israel, 7Cedars Sinai Medical Center, Los Angeles, CA, United States

Synopsis

Peri-conceptional alcohol (PCA) exposure leading to fetal alcohol spectrum disorder continues to a significant public health concern because alcohol use ceases only after recognition of pregnancy weeks after conception, but the teratogenic damages have already occurred. Our study showed that PCA exposure in mice resulted in compromised placental perfusion and placental capability to adapt to acute hypoxia challenges. Placental abnormalities due to PCA may further exacerbate fetal neurodevelopmental deficits.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Abstract

Keywords