Peri-conceptional Alcohol Exposure Shapes Placental Functions in Fetal Alcohol Spectrum Disorder
Margaret Caroline Stapleton 1, John Richard Chaillet 2, Eric Goetzman3, Devin R. E. Cortes4, Kristina Elsa Schwab1, Amanda Sferruzzi-Perri 5, Michal Neeman6, Anthony Christodoulou 7, and Yijen L Wu1
1Developmental Biology, University of Pittsburgh, Pittsburgh, PA, United States, 2Obstetrics, Gynecology & Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA, United States, 3Pediatrics, University of Pittsburgh, Pittsburgh, PA, United States, 4Biomedical Engineering, University of Pittsburgh, Pittsburgh, PA, United States, 5Physiology, University of Cambridge, Cambridge, United Kingdom, 6Biological Regulation, Weizmann Institute, Rehovot, Israel, 7Cedars Sinai Medical Center, Los Angeles, CA, United States
Peri-conceptional alcohol (PCA) exposure leading to fetal alcohol spectrum disorder continues to a significant public health concern because alcohol use ceases only after recognition of pregnancy weeks after conception, but the teratogenic damages have already occurred. Our study showed that PCA exposure in mice resulted in compromised placental perfusion and placental capability to adapt to acute hypoxia challenges. Placental abnormalities due to PCA may further exacerbate fetal neurodevelopmental deficits.
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