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Abstract #2313

Evaluation of Placenta Oxygenation and Perfusion in A Rat Model of Fetal Growth Restriction Using Quantitative T2* Mapping and 3D DCE-MRI

Fatimah Al Darwish1, Bram Coolen1, Fieke Terstappen2, Caren van Kammen2, Lindy Alles1, Raymond Schiffelers2, Titia lely2, and Gustav Strijkers1
1Biomedical engineering and physics, Amsterdam University Medical Center, Amsterdam, Netherlands, 2University Medical Center Utrecht, Utrech, Netherlands


Developing preclinical imaging techniques in the field of preeclampsia is essential to test the effectiveness of new therapeutic approaches. We applied T2* weighted and three-dimensional dynamic contrast-enhanced MRI in a pregnant rat model of reduced uterine perfusion pressure (RUPP) to test their feasibility and ability to detect differences in placental oxygenation and perfusion in RUPP rats compared to control. These techniques produced high-quality data that enabled the assessment of oxygenation and perfusion parameters. Oxygenation was decreased in RUPP placenta; however, perfusion parameters did not reveal differences, which requires further investigations.

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