We report on a multi-modal quantitative MRI/ CT imaging protocol for characterizing the comprehensive body composition and bone health in a genetically modified mouse model. Follicle stimulating hormone (FSH) is directly involved in the regulation of estrogen production, osteoclasto-genesis, and adiposity. In this study we show that the deletion of FSH gene (-/-) in the mouse results in increased adiposity and decreased tibia density in male and female mice as they age. Multi-parametric imaging provides a unique opportunity to quantify visceral adiposity levels, muscle mass, and bone density in mutant animals, non-invasively and in real time.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords