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Abstract #2314

Non-Invasive Multi-Modal Imaging of Body Composition and Bone Density in Genetically Modified Fshb Mice

Natalie Serkova1, Julia E Slack2, Jenna L Steiner3, Anna De Schutter3, Aaya AlKassi3, Jamie Henry4, and Mark S Brown3
1Radiology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States, 2Emory University, Atlanta, GA, United States, 3University of Colorado Anschutz Medical Campus, Aurora, CO, United States, 4Colorado State University, Fort Collins, CO, United States


We report on a multi-modal quantitative MRI/ CT imaging protocol for characterizing the comprehensive body composition and bone health in a genetically modified mouse model. Follicle stimulating hormone (FSH) is directly involved in the regulation of estrogen production, osteoclasto-genesis, and adiposity. In this study we show that the deletion of FSH gene (-/-) in the mouse results in increased adiposity and decreased tibia density in male and female mice as they age. Multi-parametric imaging provides a unique opportunity to quantify visceral adiposity levels, muscle mass, and bone density in mutant animals, non-invasively and in real time.

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