We report on a multi-modal quantitative MRI/ CT imaging protocol for characterizing the comprehensive body composition and bone health in a genetically modified mouse model. Follicle stimulating hormone (FSH) is directly involved in the regulation of estrogen production, osteoclasto-genesis, and adiposity. In this study we show that the deletion of FSH gene (-/-) in the mouse results in increased adiposity and decreased tibia density in male and female mice as they age. Multi-parametric imaging provides a unique opportunity to quantify visceral adiposity levels, muscle mass, and bone density in mutant animals, non-invasively and in real time.
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