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Abstract #2318

Sequence comparison and test-retest analysis for 31P-MRS in mouse brain at 7 Tesla

Antoine Cherix1, Mohamed Tachrount1, and Jason Lerch1,2
1Wellcome Centre for Integrative Neuroimaging, WIN-FMRIB, NDCN, University of Oxford, Oxford, United Kingdom, 2Mouse Imaging Centre (MICe), Hospital for Sick Children, Toronto, ON, Canada


31P-MRS is challenging in small samples as it suffers from long T1s, short T2s and low nucleus sensitivity (γ). Thus, ultra-high field has been generally preferred for investigating the mouse brain. Less is known about its feasibility at lower field strength with more readily available scanners. Here, we assess the applicability of 31P-MRS in mouse at 7T to study neuroenergetics by comparing 3D-ISIS, PRESS and sLASER. Then, by performing a test-retest analysis and power calculations we assessed the relevance of our method for potential preclinical studies application.

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