Abstract #2319

Development of in vivo dynamic nuclear polarization (DNP)-MRI at 16 mT for large animals and redox metabolic imaging of acute hepatitis rat model

Fuminori Hyodo¹, Hinako Eto², Tatsuya Naganuma³, Abdelazim Elsayed ELHELALY¹, Masaharu Murata², Yoshifumi Noda¹, Hiroki Kato¹, and Masayuki Matsuo¹

¹Gifu University, Gifu, Japan, ²Kyushu University, Fukuoka, Japan, ³Japan REDOX Limited, Fukuoka, Japan

Synopsis

To use the current methods in clinical practice, the development of a prototype in vivo DNP-MRI system for preclinical examinations of large animals is indispensable for clarifying the problems peculiar to the increase in size of the DNP-MRI device. Therefore, we developed a in vivo DNP-MRI (Overhauser MRI) system with a sample bore size of 20 cm and a 16-mT magnetic field using a U-shaped permanent magnet. The in vivo DNP-MRI system developed was used to non-invasively image the redox reaction of a carbamoyl-PROXYL probe in the livers of large rats weighing 800 g and hepatitis-model rats.

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