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Abstract #2319

Development of in vivo dynamic nuclear polarization (DNP)-MRI at 16 mT for large animals and redox metabolic imaging of acute hepatitis rat model

Fuminori Hyodo1, Hinako Eto2, Tatsuya Naganuma3, Abdelazim Elsayed ELHELALY1, Masaharu Murata2, Yoshifumi Noda1, Hiroki Kato1, and Masayuki Matsuo1
1Gifu University, Gifu, Japan, 2Kyushu University, Fukuoka, Japan, 3Japan REDOX Limited, Fukuoka, Japan


To use the current methods in clinical practice, the development of a prototype in vivo DNP-MRI system for preclinical examinations of large animals is indispensable for clarifying the problems peculiar to the increase in size of the DNP-MRI device. Therefore, we developed a in vivo DNP-MRI (Overhauser MRI) system with a sample bore size of 20 cm and a 16-mT magnetic field using a U-shaped permanent magnet. The in vivo DNP-MRI system developed was used to non-invasively image the redox reaction of a carbamoyl-PROXYL probe in the livers of large rats weighing 800 g and hepatitis-model rats.

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