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Abstract #2320

Tracking disease progression in mouse models of polycystic kidney disease with high resolution MRI and automated postprocessing

Florian Schmid1, Georgios Koukos1, Matt Sooknah1, Sanam Assili1, and Johannes Riegler1
1Calico Life Sciences, South San Francisco, CA, United States

Synopsis

We present an improved MRI acquisition and data processing pipeline to assess disease progression in mouse models of polycystic kidney disease. High-resolution anatomical T2 weighted images as well as T2 mapping are used to track changes in kidney volume, cyst burden and tissue composition. We established versatile deep-learning automatic kidney segmentation, trained on a range of kidney disease stages, animal models and image resolutions.

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