Abstract #2333

Imaging ex-vivo cynomolgus monkey brain in 150 um isotropic resolution

Chungseok Oh¹, Yu Gyeong Kim^2,3, Jeongheon Park⁴, Youngkyu Song⁴, Chang-Yeop Jeon², Kyung Seob Lim⁵, Jincheol Seo², Jung Bae Seong², Jee-Hyun Cho⁴, Youngjeon Lee², Jongho Lee¹, and Hyeong-Geol Shin¹

¹Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea, Republic of, ²National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Korea, Republic of, ³Department of Functional Genomics, KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, Korea, Republic of, ⁴Center for Research Equipment, Korea Basic Science Institute, Cheongju, Korea, Republic of, ⁵Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Korea, Republic of

Synopsis

Due to the small size of the cynomolgus brain, imaging the fine structures in the brain is a challenging task. In this study, a sample preparation method is suggested for imaging the ex-vivo cynomolgus monkey brain with sub-millimeter resolution in 7T MRI. Using the proposed method, we acquired 150 um isotropic resolution MR images for whole brain, and the fine structures in the cynomolgus monkey brain was observed.

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