Abstract #2335
Choroid plexus tissue perfusion and blood to CSF barrier function (BCSFB) in rats measured with continuous arterial spin labeling
Hedok Lee1, Burhan Ozturk1, Michael Stringer2, Bradley MacIntosh3, Douglas Rothman4, and Helene Benveniste1
1Anesthesiology, Yale School of Medicine, New Haven, CT, United States, 2Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom, 3Medical Biophysics, University of Toronto, Toronto, ON, Canada, 4Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, United States
Synopsis
In this study choroid plexus tissue perfusion and blood to CSF barrier function in rats were studied using long and short TE continuous arterial spin labeling technique. Non-mono exponential perfusion weighted signal decay in the CP was modelled by a two-compartment perfusion model and we report that partial volume effect is significant and must be considered to derive accurate choroid plexus tissue perfusion measurements.
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