Abstract #2335

Choroid plexus tissue perfusion and blood to CSF barrier function (BCSFB) in rats measured with continuous arterial spin labeling

Hedok Lee¹, Burhan Ozturk¹, Michael Stringer², Bradley MacIntosh³, Douglas Rothman⁴, and Helene Benveniste¹

¹Anesthesiology, Yale School of Medicine, New Haven, CT, United States, ²Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom, ³Medical Biophysics, University of Toronto, Toronto, ON, Canada, ⁴Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, United States

Synopsis

In this study choroid plexus tissue perfusion and blood to CSF barrier function in rats were studied using long and short TE continuous arterial spin labeling technique. Non-mono exponential perfusion weighted signal decay in the CP was modelled by a two-compartment perfusion model and we report that partial volume effect is significant and must be considered to derive accurate choroid plexus tissue perfusion measurements.

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