Abstract #2336

Evaluating ultra-short echo time (UTE) cerebral blood volume (CBV)-based fMRI using an iron-oxide contrast agent in mouse visual cortex at 9.4T

Naman Jain¹, Saskia Bollmann¹, Jonathan R. Polimeni^2,3,4, Kai-Hsiang Chuang^1,5, and Markus Barth^1,6,7

¹Centre for Advanced Imaging, St. Lucia, Australia, ²Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ³Department of Radiology, Harvard Medical School, Boston, MA, United States, ⁴Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States, ⁵Queensland Brain Institute, The University of Queensland, St. Lucia, Australia, ⁶School of Information Technology and Electrical Engineering, St. Lucia, Australia, ⁷ARC Centre for Innovation in Biomedical Imaging and Technology, The University of Queensland, St. lucia, Australia

Synopsis

CBV-based fMRI has been demonstrated to have better spatial specificity than BOLD. CBV estimates based on iron-oxide contrast agents (CA) reflect this microvascular sensitivity, however because of strong extravascular dephasing CBV changes within large vessels are more difficult to detect. Here, we measured functional CBV changes after injecting CA with UTE-MRI and found positive signal changes (+0.5%) predominantly localized at large vessels at a TE of 0.164ms, and negative signal changes (-2%) at a TE of 4ms localized within the tissue. This indicates sensitivity to different vascular compartments at different TEs reflecting the respective T1 and T2* effects of CA.

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