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Abstract #2337

Estimating Hemodynamic Response Function Using Simultaneous fMRI and Calcium Recording

Shabnam khorasani gerdekoohi1, Pankaj Sah1, and Kai-Hsiang Chuang1
1Queensland Brain Institute, The University of Queensland, Brisbane, Australia


· Evoked BOLD and calcium signals were recorded in the visual pathway using standard (TR=1s) and ultrafast (TR=0.3s) EPI of two TEs.

· Hemodynamic response function was estimated based on neuronal calcium activity. HRF estimated from ultrafast fMRI shows faster kinetics in the lateral geniculate nucleus than the visual cortex.

· BOLD signal was predicted from calcium signal convoluted by HRF. Using ultrafast fMRI significantly improved the accuracy of the predicted BOLD.

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