Abstract #2338

DTI and fMRI Biomarkers in a Pig Model of Pediatric Traumatic Brain Injury

Alesa Hughson Netzley¹, Andrew Badachhape², Lauren Wade-Kleyn³, Jie Huang⁴, Kirk Munoz⁵, Aimee Colbath⁵, Avner Meoded², and Galit Pelled¹

¹Biomedical Engineering, Michigan State University, East Lansing, MI, United States, ²Radiology, Baylor College of Medicine, Houston, TX, United States, ³Neuroscience, Michigan State University, East Lansing, MI, United States, ⁴Radiology, Michigan State University, East Lansing, MI, United States, ⁵Veterinary Medicine, Michigan State University, East Lansing, MI, United States

Synopsis

The goal of this work is to identify MRI biomarkers of mild traumatic brain injury (mTBI) using a pig model of pediatric concussion. We have found changes in the brain using DTI and fMRI in the days and weeks immediately following injury. We also collected data from a battery of cognitive, emotional, and motor assessments. Together, we anticipate these data will help us to identify biomarkers of injury that will improve diagnostics of children to decrease the risk of post-injury complications.

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