DTI and fMRI Biomarkers in a Pig Model of Pediatric Traumatic Brain Injury
Alesa Hughson Netzley1, Andrew Badachhape2, Lauren Wade-Kleyn3, Jie Huang4, Kirk Munoz5, Aimee Colbath5, Avner Meoded2, and Galit Pelled1
1Biomedical Engineering, Michigan State University, East Lansing, MI, United States, 2Radiology, Baylor College of Medicine, Houston, TX, United States, 3Neuroscience, Michigan State University, East Lansing, MI, United States, 4Radiology, Michigan State University, East Lansing, MI, United States, 5Veterinary Medicine, Michigan State University, East Lansing, MI, United States
The goal of this work is to identify MRI biomarkers of mild traumatic brain injury (mTBI) using a pig model of pediatric concussion. We have found changes in the brain using DTI and fMRI in the days and weeks immediately following injury. We also collected data from a battery of cognitive, emotional, and motor assessments. Together, we anticipate these data will help us to identify biomarkers of injury that will improve diagnostics of children to decrease the risk of post-injury complications.
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