Simultaneous Multi-Slice Acceleration of Multi-Echo EPI Provides Rapid and Accurate Quantitative Susceptibility Mapping
Oliver C. Kiersnowski1, Patrick Fuchs1, Stephen J. Wastling2,3, John S. Thornton2,3, and Karin Shmueli1
1Department of Medical Physics & Biomedical Engineering, University College London, London, United Kingdom, 2UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, 3Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom
Simultaneous multi-slice (SMS) acquisition is increasingly used to accelerate echo planar imaging (EPI). EPI acquisitions have been used for quantitative susceptibility mapping (QSM) but, to utilise SMS, an investigation into the effect of SMS on EPI-QSM accuracy is necessary. Here, we show that SMS has no significant effect on magnetic susceptibility maps and values, and can, therefore, provide accurate QSM within a short TR. We also show, for the first time, that multi-echo phase images can be acquired using an EPI sequence (highly) accelerated using SMS and parallel imaging, leading to more accurate QSM reconstruction compared to standard single-echo EPI.
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