Isotropic QSM in seconds using super-resolution 2D EPI imaging in 3 orthogonal planes
Beata Bachrata1,2, Steffen Bollmann3,4,5, Günther Grabner1,6,7, Siegfried Trattnig1,2, and Simon Daniel Robinson1,3,8
1High Field Magnetic Resonance Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University Of Vienna, Vienna, Austria, 2Karl Landsteiner Institute for Clinical Molecular MR in Musculoskeletal Imaging, Vienna, Austria, 3Centre of Advanced Imaging, University of Queensland, Brisbane, Australia, 4University of Queensland, Centre for Innovation in Biomedical Imaging Technology, Brisbane, Australia, 5School of Information Technology and Electrical Engineering, University of Queensland, Brisbane, Australia, 6Department of Medical Engineering, Carinthia University of Applied Sciences, Klagenfurt, Austria, 7Department of Neurology, Medical University Of Vienna, Vienna, Austria, 8Department of Neurology, Medical University of Graz, Graz, Austria
We propose a method to generate a super-resolution QSM from three orthogonal 2D EPI acquisitions with anisotropic voxels. Using distortion correction and non-linear co-registration of the individual EPI images with thick slices, a super-resolution EPI image with isotropic voxels was generated and used to compute a QSM. The super-resolution 2D EPI susceptibility maps, as well as the susceptibility values within deep grey matter structures, showed close correspondence to a standard GRE QSM. The net acquisition time was, however, reduced from several minutes to several seconds, allowing QSM in problematic patient cohorts and clinical routine.
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