Abstract #2368

Brain Health in Preterm Infants: Cerebral Metabolic Rate of Oxygen (CMRO2) Using Advanced MRI

Chen Shuang Zhu^1,2, Alexander Mark Weber^1,2,3, Ruth E Grunau^1,3,4, and Natalie Chan^1,3,4

¹Institute of Research, BC Children’s Hospital, Vancouver, BC, Canada, ²School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada, ³Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada, ⁴Division of Neonatology, BC Women’s Hospital, Vancouver, BC, Canada

Synopsis

Cerebral metabolic rate of oxygen (CMRO2) is a measurement of oxygen metabolism that may help determine outcomes in preterm neonates and improve treatments. However, limitations exist in current methods for measuring CMRO2. Advanced MRI techniques such as quantitative susceptibility mapping (QSM) may be able to overcome these challenges. GE 3T MRI data of preterm neonates at term equivalent age (TEA) (n=9) was obtained and analyzed using a standard equation to determine the CMRO2. CMRO2 values agreed with literature values and correlated strongly with birth age, but not with birth weight or head circumference at birth.

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