Abstract #2370

COSMOS-Based Susceptibility Estimations: Accuracy Assessment and Comparisons of QSM and Multiple-Angle Acquisitions

Dimitrios G. Gkotsoulias¹, Roland Müller ¹, Torsten Schlumm¹, Niklas Alsleben¹, Carsten Jäger¹, Jennifer Jaffe^2,3, André Pampel¹, Catherine Crockford^2,3, Roman Wittig^2,3, and Harald Möller¹

¹Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, ²Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany, ³Tai Chimpanzee Project, Centre Suisse de Recherches Scientifiques en Cote d'Ivoire, Abidjan, Cote D'ivoire

Synopsis

Calculation Of Susceptibility through Multiple Orientation Sampling (COSMOS) is assessed comparing the optimal, a clinically feasible and multiple-orientation schemes. The optimal COSMOS estimation is used as a gold standard and is compared to the other schemes using the similarity index (SSIM), mean absolute error (MAE) and Pearson’s coefficient (PC). Further comparisons include Thresholded K-space Division (TKD) quantitative susceptibility mapping. For selected white-matter regions, linear regression is used to assess the similarities between the different estimations.

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