Multi-echo sandwich spatial saturation neuromelanin (sandwichNMmulti-echo) imaging is proposed to simultaneously acquire a high-quality neuromelanin-sensitive image, a co-localized T2* map, and an improved susceptibility map weighted image for nigral hyperintensity. When this method is applied for PD patients and healthy controls, the results suggest that the reduced neuromelanin contrast in PD is partially explained by shorter T2* in substantia nigra of the PD patients. Initial results at 7T further support the finding, suggesting a need for T2* correction in assessing the NM-sensitive images.
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