Multiecho sandwich spatial saturation neuromelanin imaging: improved nigral hyperintensity and need for T2* correction in NM-sensitive images
Sooyeon Ji1, Eun-Jung Choi1, Beomseok Sohn2, Kyoungwon Baik2, Eung Yeop Kim3, In Seong Kim4, Jin Wook Choi5, Seongbeom Park6, Soohwa Song6, Dong Hoon Shin6, Phil Hyu Lee7, and Jongho Lee1
1Seoul National University, Seoul, Korea, Republic of, 2Severance Hospital, Seoul, Korea, Republic of, 3Department Radiology, Samsung Medical Center, Seoul, Korea, Republic of, 4Siemens Healthineers Ltd., Seoul, Korea, Republic of, 5Department of Radiology, Ajou University School of Medicine, Ajou University Medical Center, Suwon, Korea, Republic of, 6Heuron Co. Ltd., Incheon, Korea, Republic of, 7Department of Neurology, Severance Hospital, Seoul, Korea, Republic of
Multi-echo sandwich spatial saturation neuromelanin (sandwichNMmulti-echo) imaging is proposed to simultaneously acquire a high-quality neuromelanin-sensitive image, a co-localized T2* map, and an improved susceptibility map weighted image for nigral hyperintensity. When this method is applied for PD patients and healthy controls, the results suggest that the reduced neuromelanin contrast in PD is partially explained by shorter T2* in substantia nigra of the PD patients. Initial results at 7T further support the finding, suggesting a need for T2* correction in assessing the NM-sensitive images.
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