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Abstract #2374

Nigral Neuromelanin MRI Changes in Isolated Rapid Eye Movement Sleep Behavior Disorder Using Deep Learning

Rahul Gaurav1,2, Romain Valabrègue2, Nadya Pyatigorskaya1,2,3, Graziella Mangone4, Smaranda Leu-Semenescu5, Jean-Christophe Corvol4,6, Marie Vidailhet1,6, Isabelle Arnulf1,5, and Stephane Lehericy1,2,3
1Movement Investigations and Therapeutics Team (MOV’IT), Paris Brain Institute (ICM), Paris, France, 2CENIR, Paris Brain Institute (ICM), Paris, France, 3Department of Neuroradiology, Pitié-Salpêtrière Hospital, AP-HP, Paris, France, 4INSERM, Clinical Investigation Center for Neurosciences (CIC), Paris Brain Institute (ICM), Paris, France, 5Sleep Disorders Unit, Pitié-Salpêtrière Hospital, AP-HP, Paris, France, 6Department of Neurology, Pitié-Salpêtrière Hospital, AP-HP, Paris, France


Isolated REM sleep behavior disorder (iRBD) is considered a prodromal stage of parkinsonism. Neurodegenerative changes in the substantia nigra pars compacta (SNc) in parkinsonism can be detected using neuromelanin-sensitive MRI. In this cross-sectional, observational, case-control study, we investigated changes in neuromelanin in participants with iRBD compared to Parkinson’s disease and healthy volunteers in the SNc segmented automatically using convolutional neural network-based U-net architecture. The iRBD participants had reduced neuromelanin content at an intermediate level between the values in HV and PD patients.

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