Abstract #2377

Examination of nigral volumetric and microstructural changes in prodromal and overt Parkinson’s disease

Jason Langley¹, Kristy S. Hwang^2,3, Daniel E. Huddleston⁴, and Xiaoping Hu^1,5

¹Center for Advanced Neuroimaging, University of California Riverside, Riverside, CA, United States, ²Department of Neurosciences, University of California San Diego, San Diego, CA, United States, ³Parkinson & Other Movement Disorders Center, University of California San Diego, San Diego, CA, United States, ⁴Department of Neurology, Emory University, Atlanta, GA, United States, ⁵Department of Bioengineering, University of California Riverside, Riverside, CA, United States

Synopsis

We examine nigral volume and tissue microstructure in prodromal and symptomatic Parkinson’s disease. Decreases in nigral volume were observed in the symptomatic Parkinson's disease group relative to the control group (p<10^-3) and prodromal Parkinson's disease (p<10^-3) group. A reduction in nigral volume was seen in the prodromal Parkinson's disease group relative to the control group (p=0.025). An increase in nigral free water was also found in the symptomatic Parkinson’s disease group relative to the control group (p=0.014).

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