Quantitative Analysis of Deep Nuclei in Patients with Parkinson’s disease (PD) using STrategically Acquired Gradient Echo (STAGE) Imaging
Zhaoxi Liu1, Yiwei Zhang2, Han Wang1, Dan Xu1, Bo Wu3, E. Mark Haackeb4, Hui You1, and Feng Feng1
1Peking Union Medical College Hospital, Bejing, China, 2Peking university first hospital, Bejing, China, 3SpinTech, Inc., Bingham Farms, MI, United States, 4Wayne State University, Detroit, MI, United States
Patients with Parkinson’s disease (PD) showed increased iron deposition in the substantia nigra, red nucleus, dentate nucleus and globus pallidus compared with healthy controls. Besides, the T1 value, T2* value and R2* value of deep nucleus also altered in PD patients. Which suggested the STrategically Acquired Gradient Echo (STAGE) imaging could provide a good performance in quantitative analysis in multi-modal parameters.
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