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Abstract #2381

Sensorimotor-Related Area Abnormalities in Amyotrophic Lateral Sclerosis: An Intravoxel Incoherent Motion Magnetic Resonance Imaging Study

Jia Yan Shi1 and Hua Jun Chen2
1Fujian Medical University Union Hospital, Fuzhou, China, 2Radiology, Fujian Medical University Union Hospital, Fuzhou, China


We conducted the first assessment of the sensorimotor-related areas(SMA) alterations in ALS using IVIM MRI and atlas-based analysis, which may provide useful information for localization of specific cortex and white matter(WM) tract damage in ALS. In grey matter areas (GM), ALS patients showed a reduction in f in the bilateral preSMA and SMA, while in WM areas, ALS patients exhibited an increase in D in a WM tract projecting to the right ventral premotor cortex(PMv). Correlation analysis revealed that the average D in this right PMv tract was negatively correlated to ALS disease severity.

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