We conducted the first assessment of the sensorimotor-related areas(SMA) alterations in ALS using IVIM MRI and atlas-based analysis, which may provide useful information for localization of specific cortex and white matter(WM) tract damage in ALS. In grey matter areas (GM), ALS patients showed a reduction in f in the bilateral preSMA and SMA, while in WM areas, ALS patients exhibited an increase in D in a WM tract projecting to the right ventral premotor cortex(PMv). Correlation analysis revealed that the average D in this right PMv tract was negatively correlated to ALS disease severity.
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