Abstract #2382

Resting-State Functional Connectivity of the Central Autonomic Network (CAN) in Parkinson’s Disease

Pohchoo Seow¹, Yao-Chia Shih², Septian Hartono³, Li Rong Yin¹, Aeden Zi Cheng Kuek¹, Samuel Yong Ern Ng³, Eng King Tan³, Louis Tan³, and Ling Ling Chan¹

¹Diagnostic Radiology, Singapore General Hospital, Singapore, Singapore, ²Graduate Institute of Medicine, Yuan Ze University, Taipei, Taiwan, ³Neurology, National Neuroscience Institute, Singapore, Singapore

Synopsis

Vast evidence for network-level functional dysfunctions have been reported in Parkinson’s disease (PD). However, brain abnormalities that underlie common autonomic symptoms in PD have not been fully investigated. Resting-state functional integration of the Central Autonomic Network (CAN) of 79 PD patients and 43 healthy controls (HC) were evaluated using seed-based analysis. Significantly decreased functional connectivity between the right anterior insular seed and left lateral occipital cortex, right lingual gyrus, and left occipital pole were found in HC compared to PD. Functional connectivity analysis of the CAN facilitates further understanding of the potential mechanisms underlying altered autonomic regulation in PD.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.