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Abstract #2382

Resting-State Functional Connectivity of the Central Autonomic Network (CAN) in Parkinson’s Disease

Pohchoo Seow1, Yao-Chia Shih2, Septian Hartono3, Li Rong Yin1, Aeden Zi Cheng Kuek1, Samuel Yong Ern Ng3, Eng King Tan3, Louis Tan3, and Ling Ling Chan1
1Diagnostic Radiology, Singapore General Hospital, Singapore, Singapore, 2Graduate Institute of Medicine, Yuan Ze University, Taipei, Taiwan, 3Neurology, National Neuroscience Institute, Singapore, Singapore


Vast evidence for network-level functional dysfunctions have been reported in Parkinson’s disease (PD). However, brain abnormalities that underlie common autonomic symptoms in PD have not been fully investigated. Resting-state functional integration of the Central Autonomic Network (CAN) of 79 PD patients and 43 healthy controls (HC) were evaluated using seed-based analysis. Significantly decreased functional connectivity between the right anterior insular seed and left lateral occipital cortex, right lingual gyrus, and left occipital pole were found in HC compared to PD. Functional connectivity analysis of the CAN facilitates further understanding of the potential mechanisms underlying altered autonomic regulation in PD.

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