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Abstract #2383

Disrupted brain functional network connectivity in Parkinson’s disease patients with Mild Cognitive Impairment.

Karthik R Sreenivasan1, Xiaowei Zhuang1, Jessica Caldwell1, Aaron Ritter1, Dietmar Cordes1, Zoltan Mari1, and Virendra Mishra1
1Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States


The underlying cause of cognitive deficits in PD (PD-MCI) is not well understood and there are no biomarkers to diagnose PD-MCI. Although previous studies have found disrupted functional connectivity several factors make it difficult to generalize findings from fMRI studies. In the current study, we investigate functional network abnormalities in PD-MCI and PD patients who are cognitively normal (PD-NC). Our results were in line with earlier studies that showed altered connectivity was observed involving the frontal and striatal regions in the PD-MCI group, and we also found altered connectivity between regions in the temporal and the parietal cortex.

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