Meeting Banner
Abstract #2383

Disrupted brain functional network connectivity in Parkinson’s disease patients with Mild Cognitive Impairment.

Karthik R Sreenivasan1, Xiaowei Zhuang1, Jessica Caldwell1, Aaron Ritter1, Dietmar Cordes1, Zoltan Mari1, and Virendra Mishra1
1Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States

Synopsis

The underlying cause of cognitive deficits in PD (PD-MCI) is not well understood and there are no biomarkers to diagnose PD-MCI. Although previous studies have found disrupted functional connectivity several factors make it difficult to generalize findings from fMRI studies. In the current study, we investigate functional network abnormalities in PD-MCI and PD patients who are cognitively normal (PD-NC). Our results were in line with earlier studies that showed altered connectivity was observed involving the frontal and striatal regions in the PD-MCI group, and we also found altered connectivity between regions in the temporal and the parietal cortex.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords