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Abstract #2384

Altered functional connectivity in Parkinson’s disease with psychosis

Apoorva Safai1, Shweta Prasad2,3, Jitender Saini4, Abhishek Lenka2, Pramod Pal2, and Madhura Ingalhalikar1
1Symbiosis Centre for Medical Image Analysis, Symbiosis International University, Pune, India, 2Department of Neurology, National Institute of Mental Health & Neurosciences, Bangalore, India, 3Department of Clinical Neuroscience, National Institute of Mental Health & Neurosciences, Bangalore, India, 4Department of Neuroimaging & Interventional Radiology, National Institute of Mental Health & Neurosciences, Bangalore, India

Synopsis

Visual hallucinations (VH) is a commonly occurring psychosis symptom in Parkinson’s disease (PD). However, neuropathology of VH in PD is not clearly known, thereby limiting the efficacy of therapeutic strategies. To mitigate this gap, we evaluated functional connectivity (FC) changes and network organisation, related to VH in PD. PD patients exhibited widespread reduction in interhemispheric FC and local network topology of temporal, frontal, parietal, striatal, limbic, cerebellar, occipital and sensory motor regions. Patients with psychosis displayed larger FC reductions, particularly in cerebellar regions and their connections with frontal and occipital regions. Topological changes in temporal regions seen across PD patients

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