The main goal of this study was to investigate the changes of neurovascular coupling (NVC) in patients at early stages of Alzheimer’s disease. Patients with SCD and MCI were enrolled. Significantly changes of neurovascular coupling have been separately found between SCD, MCI patients and HCs in the regions involved the left Rolandic operculum, left anterior orbital gyrus, right insula, right parahippocampal gyrus, left lingual gyrus, median cingulate and paracingulate gyri and left supramarginal gyrus. In addition, these changes of NVC showed strong correlations with multiple clinical scales. Therefore, NVC can be an effective method for early diagnosis of SCD patients.
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