Abstract #2387

Neurovascular dysfunction in patients with subjective cognitive decline: A resting-state fMRI study

Yin Tang¹, Ling Zhang¹, Hongyuan Ding¹, Yi Zhu², Yaxin Gao³, Long Qian⁴, Weiqiang Dou⁴, and Ming Qi¹

¹Radiology department, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, ²Rehabilitation Department, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, ³Rehabilitation Department, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China, ⁴MR Research China, GE Healthcare, Beijing, China

Synopsis

The main goal of this study was to investigate the changes of neurovascular coupling (NVC) in patients at early stages of Alzheimer’s disease. Patients with SCD and MCI were enrolled. Significantly changes of neurovascular coupling have been separately found between SCD, MCI patients and HCs in the regions involved the left Rolandic operculum, left anterior orbital gyrus, right insula, right parahippocampal gyrus, left lingual gyrus, median cingulate and paracingulate gyri and left supramarginal gyrus. In addition, these changes of NVC showed strong correlations with multiple clinical scales. Therefore, NVC can be an effective method for early diagnosis of SCD patients.

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