Functional connectivity, measured with BOLD-fMRI, has been previously used to study changes in aging and Alzheimer’s disease. A combined spin- and gradient-echo (SAGE) acquisition may be able to more sensitively distinguish between disease-related changes in functional connectivity. Therefore, this study aims to implement SAGE in resting-state fMRI to assess differences between macro- and microvasculature-sensitive data, between SAGE maps and single-echo methods, and between healthy aging and cognitively impaired cohorts’ functional networks.
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