Abstract #2389

Choroid plexus changes in clinically defined Alzheimer disease spectrum: Volumetry, QSM and BBB permeability imaging

Won-Jin Moon¹, Jong Duck Choi¹, Yeonsil Moon², Hee Jin Kim³, Younghee Yim⁴, and Subin Lee⁵

¹Radiology, Konkuk University Medical Center, Seoul, Korea, Republic of, ²Neurology, Konkuk University Medical Center, Seoul, Korea, Republic of, ³Neurology, Hanyang University Hospital, Seoul, Korea, Republic of, ⁴Radiology, Chung-Ang University Hospital, Seoul, Korea, Republic of, ⁵Electrical and Computer Engineering, Seoul National University, Seoul, Korea, Republic of

Synopsis

In patients with cognitive impairment spectrum, 3T MRI revealed that choroid plexus volume and permeability was associated with cognitive impairment severity. l In patients with cognitive impairment, choroid plexus (CP) volume followed this order: Alzheimer dementia > late mild cognitive impairment (MCI) > early MCI or subjective cognitive impairment (p<.001) l Large CP volume was associated with lower Ktrans (r=-0.403, p=.006) and Vp (r=-0.543, p=.003) l Increased CP volume was negatively associated with memory function (B=-0.6662, SE=0.2089, p=.002), frontal executive function (B=-0.8973, SE=0.3145, p=.005), and mini-mental status examination score (B=-0.8158, SE=0.3153, p=.01) after adjusting for covariates.

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