Abstract #2392

Neuroimaging of a novel mouse model of Alzheimer’s Disease: The hAβKI mouse.

Andre Obenaus¹, Amandine Jullienne¹, Brenda Patricia Noarbe¹, Ashley A Keiser², Michelle Vy Trinh¹, Eniko Kramar², Joy Beardwood², Tri Dong², Marcelo Wood², and MODEL AD³

¹Pediatrics, University of California, Irvine, Irvine, CA, United States, ²Neurobiology and Behavior, University of California, Irvine, Irvine, CA, United States, ³University of California, Irvine, Irvine, CA, United States

Synopsis

Mouse models of Alzheimer’s disease (AD) currently do not recapitulate accurately the human disease. The MODEL-AD consortium has recently developed new mouse models of AD, including the human amyloid β knockin (hAβKI) mouse. Using high resolution diffusion MRI (dMRI) we examined regional changes in the hAβKI male and female mouse across its lifespan (4-18mo). Sex and regional differences were apparent with age, including reduced diffusion metrics in the hippocampus, that mirrored altered learning and memory. Preclinical MR phenotyping allows for cross-species comparisons for biomarker identification.

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