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Abstract #2392

Neuroimaging of a novel mouse model of Alzheimer’s Disease: The hAβKI mouse.

Andre Obenaus1, Amandine Jullienne1, Brenda Patricia Noarbe1, Ashley A Keiser2, Michelle Vy Trinh1, Eniko Kramar2, Joy Beardwood2, Tri Dong2, Marcelo Wood2, and MODEL AD3
1Pediatrics, University of California, Irvine, Irvine, CA, United States, 2Neurobiology and Behavior, University of California, Irvine, Irvine, CA, United States, 3University of California, Irvine, Irvine, CA, United States


Mouse models of Alzheimer’s disease (AD) currently do not recapitulate accurately the human disease. The MODEL-AD consortium has recently developed new mouse models of AD, including the human amyloid β knockin (hAβKI) mouse. Using high resolution diffusion MRI (dMRI) we examined regional changes in the hAβKI male and female mouse across its lifespan (4-18mo). Sex and regional differences were apparent with age, including reduced diffusion metrics in the hippocampus, that mirrored altered learning and memory. Preclinical MR phenotyping allows for cross-species comparisons for biomarker identification.

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