Abstract #2393

Early microstructural aberrations in a mouse model of Alzheimer’s disease detected by Soma and Neurite Density Imaging

Andrada Ianus¹, Renata Cruz¹, Cristina Chavarrias¹, Marco Palombo^2,3,4, and Noam Shemesh¹

¹Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, Portugal, ²Centre for Medical Image Computing (CMIC), Dept of Computer Science, University College London, London, United Kingdom, ³Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom, ⁴School of Computer Science and Informatics, Cardiff University, Cardiff, United Kingdom

Synopsis

Alzheimer’s disease induces early morphological tissue changes which precede the onset of symptoms and can be important targets for neuroimaging. In this work we employ Soma and Neurite Density Imaging (SANDI), a biophysical modelling approach for diffusion MRI, to investigate tissue microstructure alterations in the 3xTg AD mouse model and compare it with the state-of-the-art Diffusion Kurtosis Imaging (DKI).

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.