In patients with Fontan, although liver stiffness has been found to increase significantly with age and has been directly correlated with diminished cardiac function, the increased liver stiffness could be influenced by underlying conditions of vascular congestion. The purpose of this study was to compare stiffness as measured by MRE localized by liver biopsy with histological results from biopsy, and to determine the change in MRE defined liver stiffness over time. Our findings have important implications for how liver MRE might be a useful tool in following the progression of liver stiffness longitudinally in patients with Fontan associated liver disease.
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