Abstract #2410

Metabolic bone response to exercise loading is predictive of joint degeneration after 2 years in OA knees

Janelle Baker¹, James MacKay², Feliks Kogan³, and Lauren Watkins^3,4

¹Biomechanical Engineering, Stanford University, Stanford, CA, United States, ²Radiology, Cambridge University, Cambridge, United Kingdom, ³Radiology, Stanford University, Stanford, CA, United States, ⁴Steadman Philippon Research Institute, Vail, CO, United States

Synopsis

Hybrid [¹⁸F]sodium fluoride PET-MRI was used to evaluate the relationship between the bone metabolic response to exercise and joint changes over two years in osteoarthritic (OA) knees, including changes in cartilage T2 relaxation times as well as structural changes in bone and cartilage. Regions in OA knees that experienced structural changes over two years had increased PET metabolic bone response to exercise compared to regions that did not. Bone response to exercise may be a useful metric to predict joint changes in OA.

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