This research utilizes a novel high-resolution phase-contrast (PC) MRI method to measure resting-state fluctuation of cerebral blood flow-related velocity (CBFv) from penetrating vessels in the rat parietal cortex. This novel PC-based mapping scheme has identified vessel-specific correlation and anti-correlation patterns between venules and arterioles with the low-frequency oscillatory features less than 0.05Hz in anesthetized rat brains. By combining PC-based CBFv fMRI and single-vessel cerebral blood volume (CBV)-fMRI, we will further study the vasodynamic changes in diseased animal models.
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