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Abstract #2411

Resting-state single-vessel cerebral blood velocity by phase contrast fMRI

Yuanyuan Jiang1, David Christopher Hike1, and Xin Yu1
1Massachusetts General Hospital, Martinos Center for Biomedical Imaging, Charlestown, MA, United States


This research utilizes a novel high-resolution phase-contrast (PC) MRI method to measure resting-state fluctuation of cerebral blood flow-related velocity (CBFv) from penetrating vessels in the rat parietal cortex. This novel PC-based mapping scheme has identified vessel-specific correlation and anti-correlation patterns between venules and arterioles with the low-frequency oscillatory features less than 0.05Hz in anesthetized rat brains. By combining PC-based CBFv fMRI and single-vessel cerebral blood volume (CBV)-fMRI, we will further study the vasodynamic changes in diseased animal models.

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