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Abstract #2412

Bilateral homotopic rs-fMRI connectivity strength is not primarily mediated by direct corticocortical interaction

Won Beom Jung1, Haiyan Jiang1,2, and Seong-Gi Kim1,2
1Center for Neuroscience Imaging Research (CNIR), Suwon, Korea, Republic of, 2Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of


Functional connectivity measured by rs-fMRI have generally shown a bilateral organization in homotopic cortices, presumably related to the intrinsic network of spontaneous activity. Alternatively, cortical silencing suppresses spontaneous output activity from the inactivated site and reduces input to downstream areas. Thus, the decrease in fMRI responses due to cortical silencing is related to the strength of resting-state connectivity between the stimulation site and the connected regions. To examine the contribution of spontaneous neuronal communications to bilateral homotopic connectivity of rs-MRI, we compared the somatosensory network by rs-fMRI with cortical silencing fMRI by optogenetic stimulation of interneurons and anatomical tracing data.

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