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Abstract #2421

Cross-Linked Protoporphyrin IX polymer as Efficient, Tunable CEST MRI NanoPlatform for molecular Imaging

Xiaoxiao Zhang1, Zhigang Wu1, Peng Sun1, Zhiwei Shen1, Liangjie Lin1, Geli Hu1, Haoyu Huang1, and Jiazheng Wang1
1Philips Healthcare, Wuhan, China


CEST MRI is an novel molecular imaging technique in which the contrast is generated by the dynamic exchange between the exchangeable proton and water. Porphyrin and its analogues are a promising class of highly sensitive, diamagnetic CEST agents with highly upfield shifted protons. We synthesized a water-soluble polymeric CEST MRI agent grafted with protoporphyrin IX(PpIX). The PpIX polymeric agent resonated at -13.5 ppm from water and showed excellent CEST MRI properties.

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