CEST MRI is an novel molecular imaging technique in which the contrast is generated by the dynamic exchange between the exchangeable proton and water. Porphyrin and its analogues are a promising class of highly sensitive, diamagnetic CEST agents with highly upfield shifted protons. We synthesized a water-soluble polymeric CEST MRI agent grafted with protoporphyrin IX(PpIX). The PpIX polymeric agent resonated at -13.5 ppm from water and showed excellent CEST MRI properties.
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