A Highly Water-soluble Hemin-Based Polymeric Contrast Agents for Magnetic Resonance Imaging
Xiaoling Gong1, Xiaoxiao Zhang2, Xiaoyong Zhang3, Kai Ai4, and Bing Wu5
1Departments of Radiology, West China Hospital, Sichuan University, Cheng du, China, 2Department of Clinical, Philips Healthcare, China, Wuhan, China, 3Department of Clinical, Philips Healthcare, China, Chengdu, China, 4Department of Clinical, Philips Healthcare, China, Xian, China, 5Departments of Radiology, West China Hospital, Sichuan University, Chengdu, China
Contrast agents play a significant role in clinical MRI and are administered to detect pathology in over a third of clinical scans. Gadolinium (Gd)-based contrast agents (GBCAs) are the mainstream MRI contrast agents used in the clinic. Although GBCAs have shown efficacy and are safe to use with most patients, some GBCAs have a small risk of adverse effects, such as nephrogenic systemic fibrosis (NSF) and gadolinium deposition in the human brain. Therefore, developing novel Gd-free MRI contrast agents are in great demand. Herein, we developed a new type of MRI contrast agent using naturally derived hemin to shorten the T1 relaxation time of water.
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