Abstract #2422

A Highly Water-soluble Hemin-Based Polymeric Contrast Agents for Magnetic Resonance Imaging

Xiaoling Gong¹, Xiaoxiao Zhang², Xiaoyong Zhang³, Kai Ai⁴, and Bing Wu⁵

¹Departments of Radiology, West China Hospital, Sichuan University, Cheng du, China, ²Department of Clinical, Philips Healthcare, China, Wuhan, China, ³Department of Clinical, Philips Healthcare, China, Chengdu, China, ⁴Department of Clinical, Philips Healthcare, China, Xian, China, ⁵Departments of Radiology, West China Hospital, Sichuan University, Chengdu, China

Synopsis

Contrast agents play a significant role in clinical MRI and are administered to detect pathology in over a third of clinical scans. Gadolinium (Gd)-based contrast agents (GBCAs) are the mainstream MRI contrast agents used in the clinic. Although GBCAs have shown efficacy and are safe to use with most patients, some GBCAs have a small risk of adverse effects, such as nephrogenic systemic fibrosis (NSF) and gadolinium deposition in the human brain. Therefore, developing novel Gd-free MRI contrast agents are in great demand. Herein, we developed a new type of MRI contrast agent using naturally derived hemin to shorten the T1 relaxation time of water.

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